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KMID : 0191120130280060965
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Journal of Korean Medical Science
2013 Volume.28 No. 6 p.965 ~ p.968
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Association between Methylenetetrahydrofolate Reductase C677T Polymorphism and Bone Mineral Density: The Dong-gu Study and the Namwon Study
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Shin Min-Ho
Choi Jin-Su
Rhee Jung-Ae
Lee Young-Hoon
Nam Hae-Sung
Jeong Seul-Ki
Park Kyeong-Soo
Kim Hye-Yeon
Ryu So-Yeon
Choi Seong-Woo
Song Hye-Rim
Kim Hee-Nam
Jane A. Cauley
Kweon Sun-Seog
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Abstract
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The purpose of this study was to examine the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and bone mineral density (BMD). Two large cohort studies were performed: the Dong-gu Study (3,621 men and 5,409 women) and the Namwon Study (3,703 men and 5,672 women). We assessed lumbar spine and femoral neck BMD by dual-energy X-ray absorptiometry. Genotypes were determined by real-time polymerase chain reaction. Multiple linear regression analysis was performed to evaluate the association between MTHFR C677T and BMD, adjusting for age, weight and height. The MTHFR C677T genotype frequencies for CC, CT, and TT genotypes were 34.5, 48.7, and 16.8%, respectively, in the Dong-gu Study and 33.6, 49.2, and 17.2%, respectively, in the Namwon Study. There are no significant differences between the MTHFR C677T genotype and the BMD at the lumbar spine and femoral neck in men or women in both cohorts.
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KEYWORD
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Bone Density, Methylenetetrahydrofolate Reductase, Polymorphism, Genetic
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